Hamel



UNITED s Ans HARLEY W..RHODDHAMEL, F INDIANAPOLIS, INDIANA, ASSIGNOR TO THE ELI LILLY AND COMPANY, OF INDIANAPOLIS. INDIANA, ACORPOBATION OF INDIANA.

COMPOUNDS OF HALOGEN ACIDS WITH 2-PHENYL QUINOLIN l-CARBOXYLIC ACID.

No Drawing.

To all whom may concern Be it known that I, HARL'EY W. RHODE- HAMEL', a citizen of'the United States, residing at Indianapolis, Marion; county, and

5 State of Indiana, have invented and discovered certain new andus'eful Improvements in Compounds ,of FHaIogen Acids with Phenyl" Quinolin l-Carboxylic Acid, of

which the following is a specification.

melt at 2439 C. This compound is an especially valuable medicinal product, combining as it does the therapeutic properties of 2 phenyl quinolin 4-carboxy1ic acid and hydriodic acid, both of which are used in the treatment of rheumatism and gout. The 26 hydrobroinid forms brownishj-yellow crys- Myinvention relates to the previously 1111- l known combinations of halogen acids with acid: by drying.

Speciflcation of Letters Patent. Patented June 10, 19119. Application filed mama so, 1918. Serial No. 22 5,727.

tals which meltat 255 C. The hydrochlorid and hydrofluorid form lemon yellow crystals. The hydrochlorid melts at 223 C.

Having thus described my invention, what I claim is: I 1

1. A compound of Q-phenyl, quinolin 4:.- carbox lic acid and a halogen acid.

2. T e hydriodid of 2-phenyl quinolin 4- carboxylic acid.

. 3. The process of treating 2-phenyl quinolin 4-carboxylic acid with an excess of a halogen acid and then r moving the excess 4.,The process of treating 2-phenyl quinolin 4-carboxylic acid with an excess of hydriodic acid and thenre'moving the excess acid by drying. I

"In witness whereof, I have hereunto set my hand and seal at Indianapolis, Indiana,

this 22nd day of March, D. nineteen hundred and eighteen,

HARLEY W- EHODEHAMEL. Witnesses:

WALTER Hoovniz, FRANK R. ELDRED. 

